Intermediate

1.Lisinopril intermediates:

[1] Ethyl β-benzoylacrylate(for ACEI) 　
　
　　　　　　　　　　　　C12H12O3　 204.23
Appearance: Yellowish to reddish liquid
Assay（GC）：≥95％ or ≥97％
Package: 200Kg/Drum
Storage: Preserve in well-closed containers, Protected from light.

[2] N6-Trifluoroacetyl-L-lysine (for lisinopril)　
　
　　　　　　　　　　　　　　C8H13N2O3F3 　242
　　　　　　　　　　　　　　CAS：10009-20-8
Appearance: White or off-white crystalline powder
Assay(HPLC):≥98.0%
Package: 25Kg/Drum
Storage: Preserve in well-closed containers, Protected from light.

[3] N6-trifluoroacetyl-L-lysyl-L-proline (for lisinopril)

　　　　　　　　　C13H20F3N304　　339.0
　　　　　　　　　CAS：103300-89-6
Appearance：A yellow to orange color, lucid liquid
Assay: 15.0%～25.0%
Purity (HPLC): ≥80.0％

[4] N2- (1-(S)-ethoxycarbonyl-3-phenylpropyl)-N6-trifluoroacetyl-L-lysine (for lisinopril)

　　　　　　　　　　　　C20H27F3N205　432.44
　　　　　　　　　　　　CAS：116169-90-5
Appearance: White or off-white crystalline powder
Assay (HPLC):≥95% or ≥98.0%
Package: 25Kg/Drum
Storage: Preserve in well-closed containers, Protected from light.

[5] N2- (1-(S)-ethoxycarbonyl-3-phenylpropyl)-N6-trifluoroacetyl-L-lysine-L-proline (for lisinopril)

　　　　　　　　　　　　　　　　　　C25H34N3O6F3 529.56
　　　　　　　　　　　　　　　　　　CAS:103300-91-0
Appearance: liquid
Assay（HPLC）：≥30%
Purity：≥90% 或≥95%
Package: 50Kg/Drum or 180Kg/Drum
Storage: Preserve in well-closed containers, Protected from light.